Briesewitz was born in Leverkusen, Germany. She was exposed to film at an early age, watching them on German television, eventually cultivating a preference for French Nouvelle Vague and Italian cinema. In an interview, she recounted that Francois Truffaut's Day for Night, The Story of Adele H and The Man Who Loved Women, were some of the films that made strong impressions on her as a child. Later, Briesewitz considered training to be a painter, but decided it was too isolated as a career.
She had an internship with a German television company, before she applied and completed a cinematography program at AFI Conservatory.
In 2007 she won a Women in Film Crystal + Lucy Awards in the category Kodak Vision award.
- Briesewitz is the first female to direct more than one episode of Stranger Things.
- Briesewitz has also directed episodes for Jessica Jones and Luke Cage.