|This article is about the show's version. For the comic version, see Francine.|
On September 8, Six was being guided by Dr. Ellis into another room at Hawkins Lab. Meanwhile, Dr. Brenner was experimenting with Ten to see if he could locate Dr. Ellis and Ten with his mind. Ten finds them, saying Six is doing an experiment with a red block, but begins to hyperventilate when he says Six and Dr. Ellis are screaming. The lab is soon thrown into chaos as the alarm bells go off and screams erupt from the hallway. Ten then confirms to Dr. Brenner that Six and Dr. Ellis are both killed when Dr. Brenner tries to use the phones. The door to the room Dr. Brenner and Ten are in swings off of its hinges, knocking Brenner unconscious and killing Ten from the impact. Brenner awakens to find most of their experiments, including Six, dead. Brenner would later discover One to be responsible for killing Six, Ten, and the other test subjects through surveillance footage after Eleven banished One to the Upside Down by using her powers at an extremely high limit.
|Season Four appearances|
|The Hellfire Club*|
- Six is one of the few test subjects to replace a previous test subject who branded the same number, along with Three and Nine.
|Hawkins National Laboratory|
|Objects & Items|