Dr. Owens joins the main characters in their journey
The Mind Flayer is the overarching villain, not Vecna
More Demodogs & multiple Demogorgons
The return of the 1983 Demogorgon (I don't believe that it's dead, and I also believe that it was special to some extent since it had telekinetic abilities)
Returning to more old memories (maybe a sequence in a mind version of the Starcourt Mall)
Visions of Barb, Bob, Billy, and Brenner
The final fight takes place in the Hawkins Lab
Jopper, Stancy, and Mileven being endgame (unless Eleven dies, which she won't based on a recent MBB interview)
Murray, Owens, Hopper, and Joyce survive
One of the kids dies (preferably Will)
The 1983 Demogorgon kills one of the main cast members
Kali returns and helps Eleven train, and maybe uncover some more HNL mystery
Eleven uses memories of Terry Ives in the final battle
Something happens to Terry (positive or negative) after the final battle
Dmitri and his son are shown in the epilogue (maybe even Yuri)
Kline makes an appearance
More of the Flayed
More tunnels (this has been confirmed, I'm so excited)
Karen joins the fight